
Effects of Concurrent Alcohol Consumption and Acetaminophen Toxicity: Mechanism
This is a rough write up, please bear with me.
NAPQI is the toxic metabolite in acetaminophen-induced hepatotoxicity. NAPQI is only produced when pathways of acetaminophen clearance, including clearance of NAPQI itself, are overwhelmed. CYP2E1 is the enzyme which converts acetaminophen into NAPQI. Normally this isn’t a big deal,